What does fenclonine mean?
Definitions for fenclonine
fen·clo·nine
This dictionary definitions page includes all the possible meanings, example usage and translations of the word fenclonine.
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Wikipedia
Fenclonine
Fenclonine, also known as para-chlorophenylalanine (PCPA), acts as a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin.It has been used experimentally to treat carcinoid syndrome, but the side effects, mostly hypersensitivity reactions and psychiatric disturbances, have prevented development for this use.The effects of serotonin depletion from fenclonine are so drastic that serotonin cannot even be detected immunohistochemically within the first day after administration of a control dose. Tryptophan hydroxylase activity can be detected neither in cell bodies or nerve terminals. After one week 10% of control values (the baseline extrapolated for the study) had replenished in the raphe nucleus, and after two weeks from initial treatment as much was again detected in the hypothalamus region. Aromatic L-amino acid decarboxylase (AADC) levels were at no time affected.It is used in scientific research in humans and animals to investigate the effects of serotonin depletion.
Wikidata
Fenclonine
Fenclonine, also known as para-chlorophenylalanine, is a synthetic amino acid which acts as a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine consequently depletes serotonin in the body and reduces its actions, acting as an indirect serotonin antagonist. It is used in scientific research to investigate the effects of serotonin depletion on behaviour.
U.S. National Library of Medicine
Fenclonine
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Numerology
Chaldean Numerology
The numerical value of fenclonine in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of fenclonine in Pythagorean Numerology is: 7
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"fenclonine." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/fenclonine>.
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