Definitions for factor VIII
fac·tor vi·i·i

Princeton's WordNetRate this definition:0.0 / 0 votes

1. antihemophilic factor, antihaemophilic factor, antihemophilic globulin, antihaemophilic globulin, factor VIII, Hemofilnoun

   a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A

WikipediaRate this definition:0.0 / 0 votes

1. Factor VIII

   Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot.Factor VIII participates in blood coagulation; it is a cofactor for factor IXa, which, in the presence of Ca2+ and phospholipids, forms a complex that converts factor X to the activated form Xa. The factor VIII gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity.People with high levels of factor VIII are at increased risk for deep vein thrombosis and pulmonary embolism. Copper is a required cofactor for factor VIII and copper deficiency is known to increase the activity of factor VIII.There is a formulation as a medication that is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

ChatGPTRate this definition:0.0 / 0 votes

1. factor VIII

   Factor VIII is a blood-clotting protein that is essential for normal clotting and prevention of excessive bleeding. A deficiency or malfunction of Factor VIII can lead to hemophilia A, a hereditary bleeding disorder. It is produced in the liver and circulates in the bloodstream in an inactive form, until it is activated by various mechanisms during bleeding.

WikidataRate this definition:0.0 / 0 votes

1. Factor VIII

   Factor VIII is an essential blood-clotting protein, also known as anti-hemophilic factor. In humans, factor VIII is encoded by the F8 gene. Defects in this gene results in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot. Factor VIII participates in blood coagulation; it is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids forms a complex that converts factor X to the activated form Xa. The factor VIII gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Factor VIII

   Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

Matched Categories

1. • Coagulation Factor

How to pronounce factor VIII?

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How to say factor VIII in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of factor VIII in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of factor VIII in Pythagorean Numerology is: 4

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=factor VIII
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Factor_Viii
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=factor VIII