Definitions for etoposide
This page provides all possible meanings and translations of the word etoposide
A derivative of podophyllotoxin that is used in the treatment of some cancers by inhibiting mitosis
Etoposide, etoposide phosphate or VP-16 is a cytotoxic agent, which belongs to the drug type topoisomerase inhibitor.
U.S. National Library of Medicine
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
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