Definitions for erdheim-chester disease
polyostotic sclerosing histiocytosis, a rare disease characterized by the abnormal multiplication of histiocytes.
U.S. National Library of Medicine
A rare form of non-Langerhans-cell histiocytosis (HISTIOCYTOSIS, NON-LANGERHANS-CELL) with onset in middle age. The systemic disease is characterized by infiltration of lipid-laden macrophages, multinucleated giant cells, an inflammatory infiltrate of lymphocytes and histiocytes in the bone marrow, and a generalized sclerosis of the long bones.
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