Definitions for eif-2 kinase

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  1. EIF-2 kinase

    eIF-2 is a kinase enzyme that phosphorylates eIF-2. There are four forms in mammals: ⁕EIF2AK1: heme-regulated inhibitor kinase ⁕EIF2AK2: the double-stranded RNA-dependent kinase ⁕EIF2AK3: PEK/PERK ⁕EIF2AK4: GCN2 These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes in response to various cellular stress response's.

U.S. National Library of Medicine

  1. eIF-2 Kinase

    A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.

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