Definitions for droxidopa
This page provides all possible meanings and translations of the word droxidopa
U.S. National Library of Medicine
A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Droxidopa is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine and epinephrine. Unlike norepinephrine and epinephrine themselves, droxidopa is capable of crossing the protective blood–brain barrier.
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