What does diphthamide mean?
Definitions for diphthamide
diph·thamide
This dictionary definitions page includes all the possible meanings, example usage and translations of the word diphthamide.
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Wiktionary
diphthamidenoun
A modified histidine amino acid which renders the elongation factor inactive.
Wikipedia
Diphthamide
Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2).
Wikidata
Diphthamide
Diphthamide is a modified histidine amino acid found in eukaryotic elongation factor 2. It is usually found at position H715 in mammalian eEF2. This residue is modified by the protein encoded by the OVCA1 gene. DPH1 knockout mice are inviable while heterozygotes develop diverse types of carcinomas and sarcomas. In humans, OVCA1 is frequently found mutated in ovarian cancer. Loss of heterozygosity has taken place in 50% of benign tumours, and 90% of end-stage ovarian tumours. It is ADP-ribosylated by diphtheria toxin, hence the name, which renders the elongation factor inactive.
Numerology
Chaldean Numerology
The numerical value of diphthamide in Chaldean Numerology is: 6
Pythagorean Numerology
The numerical value of diphthamide in Pythagorean Numerology is: 7
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"diphthamide." Definitions.net. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.definitions.net/definition/diphthamide>.
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