Definitions for dideoxyadenosine
This page provides all possible meanings and translations of the word dideoxyadenosine
A synthetic nucleoside analogue of deoxyadenosine and a prodrug of didanosine in which the 3' hydroxyl group on the ribose moiety is replaced by a hydrogen atom. Dideoxyadenosine competitively inhibits adenylyl cyclase, thereby reducing levels of cyclic adenosine monophosphate (cAMP). By inhibiting cAMP-mediated gene activation in tumor cells, this agent may retard tumor cell proliferation. (NCI04)
U.S. National Library of Medicine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
Find a translation for the dideoxyadenosine definition in other languages:
Select another language:
Discuss these dideoxyadenosine definitions with the community:
Use the citation below to add this definition to your bibliography:
"dideoxyadenosine." Definitions.net. STANDS4 LLC, 2014. Web. 2 Sep. 2014. <http://www.definitions.net/definition/dideoxyadenosine>.