Definitions for diacylglycerol kinase

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  1. Diacylglycerol kinase

    Diacylglycerol kinase is a family of enzymes that catalyzes the conversion of diacylglycerol to phosphatidic acid utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low allowing DAG to be used for glycerophospholipid biosynthesis but on receptor activation of the phosphoinositide pathway, DGK activity increases driving the conversion of DAG to PA. As both lipids are thought to function as bioactive lipid signaling molecules with distinct cellular targets, DGK therefore occupies an important position, effectively serving as a switch by terminating the signalling of one lipid while simultaneously activating signalling by another. In bacteria, DGK is very small membrane protein which seems to contain three transmembrane domains. The best conserved region is a stretch of 12 residues which are located in a cytoplasmic loop between the second and third transmembrane domains. Some Gram-positive bacteria also encode a soluble diacylglycerol kinase capable of reintroducing DAG into the phospholipid biosynthesis pathway. DAG accumulates in Gram-positive bacteria as a result of the transfer of glycerol-1-phosphate moieties from phosphatidylglycerol to lipotechoic acid.

U.S. National Library of Medicine

  1. Diacylglycerol Kinase

    An enzyme of the transferase class that uses ATP to catalyze the phosphorylation of diacylglycerol to a phosphatidate. EC 2.7.1.107.

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"diacylglycerol kinase." Definitions.net. STANDS4 LLC, 2015. Web. 29 Jul 2015. <http://www.definitions.net/definition/diacylglycerol kinase>.

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