1. (verb)denature add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb
2. (verb)denature modify (as a native protein) especially by heat, acid, alkali, or ultravioletradiation so that all of the original properties are removed or diminished
3. (verb)denature make (alcohol) unfit for drinking without impairing usefulness for other purposes