Definitions for conformational entropy
con·for·ma·tion·al en·tropy

Princeton's WordNetRate this definition:4.0 / 1 vote

1. conformational entropynoun

   entropy calculated from the probability that a state could be reached by chance alone

WikipediaRate this definition:0.0 / 0 votes

1. Conformational entropy

   In chemical thermodynamics, conformational entropy is the entropy associated with the number of conformations of a molecule. The concept is most commonly applied to biological macromolecules such as proteins and RNA, but also be used for polysaccharides and other molecules. To calculate the conformational entropy, the possible conformations of the molecule may first be discretized into a finite number of states, usually characterized by unique combinations of certain structural parameters, each of which has been assigned an energy. In proteins, backbone dihedral angles and side chain rotamers are commonly used as parameters, and in RNA the base pairing pattern may be used. These characteristics are used to define the degrees of freedom (in the statistical mechanics sense of a possible "microstate"). The conformational entropy associated with a particular structure or state, such as an alpha-helix, a folded or an unfolded protein structure, is then dependent on the probability of the occupancy of that structure. The entropy of heterogeneous random coil or denatured proteins is significantly higher than that of the tertiary structure of its folded native state.

ChatGPTRate this definition:0.0 / 0 votes

1. conformational entropy

   Conformational entropy is a term used in physical chemistry and biochemistry to describe the entropy associated with the number of conformations that a molecule can adopt. It is a measure of the randomness or disorder of a system, related to the different spatial arrangements a molecule can take due to rotation about single bonds. It is important in processes like protein folding, where a molecule could potentially adopt many different shapes, but typically settles into one or a few stable configurations. The entropy decreases when the molecule assumes a specific conformation, and increases when it has more freedom to assume various conformations.

WikidataRate this definition:4.0 / 4 votes

1. Conformational entropy

   Conformational entropy is the entropy associated with the physical arrangement of a polymer chain that assumes a compact or globular state in solution. The concept is most commonly applied to biological macromolecules such as proteins and RNA, but can also be used for polysaccharides and other polymeric organic compounds. To calculate the conformational entropy, the possible conformations assumed by the polymer may first be discretized into a finite number of states, usually characterized by unique combinations of certain structural parameters, each of which has been assigned an energy level. In proteins, backbone dihedral angles and side chain rotamers are commonly used as descriptors, and in RNA the base pairing pattern is used. These characteristics are used to define the degrees of freedom. The conformational entropy associated with a particular conformation is then dependent on the probability associated with the occupancy of that state, as determined by the sum of the energies associated with the value of each parameter assumed in the state. The entropy of heterogeneous random coil or denatured proteins is significantly higher than that of the folded native state tertiary structure. In particular, the conformational entropy of the amino acid side chains in a protein is thought to be a major contributor to the energetic stabilization of the denatured state and thus a barrier to protein folding. However, a recent study has shown that side-chain conformational entropy can stabilize native structures among alternative compact structures. The conformational entropy of RNA and proteins can be estimated; for example, empirical methods to estimate the loss of conformational entropy in a particular side chain on incorporation into a folded protein can roughly predict the effects of particular point mutations in a protein. Side-chain conformational entropies can be defined as Boltzmann sampling over all possible rotameric states:

Matched Categories

1. • Entropy

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Numerology

1. Chaldean Numerology

   The numerical value of conformational entropy in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of conformational entropy in Pythagorean Numerology is: 8

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=conformational entropy
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Conformational_Entropy
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=conformational entropy