1. (noun)commerce, commercialism, mercantilism transactions (sales and purchases) having the objective of supplying commodities (goods and services)
2. (noun)Department of Commerce, Commerce Department, Commerce, DoC the United States federaldepartment that promotes and administers domestic and foreign trade (including management of the census and the patent office); created in 1913
3. (noun)commerce social exchange, especially of opinions, attitudes, etc.