Definitions for coagulasekoʊˈæg yəˌleɪs, -ˌleɪz
This page provides all possible meanings and translations of the word coagulase
Random House Webster's College Dictionary
co•ag•u•lasekoʊˈæg yəˌleɪs, -ˌleɪz(n.)
an enzyme that causes coagulation, esp. of the blood.
Origin of coagulase:
an enzyme that induces coagulation
Any enzyme that induces coagulation
Specifically, the enzyme produced by various Staphylococcus species that converts fibrinogen to fibrin
Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is coagulase-positive, meaning that coagulase negativity excludes S. aureus. It is also produced by Yersinia pestis. Coagulase reacts with prothrombin in the blood. The resulting complex is called staphylothrombin, which enables the enzyme protease to convert fibrinogen to fibrin. This results in clotting of the blood. Coagulase is tightly bound to the surface of the bacterium S. aureus and can coat its surface with fibrin upon contact with blood. It has been proposed that fibrin-coated staphylococci resist phagocytosis, making the bacteria more virulent. Bound coagulase is part of the larger family of MSCRAMM.
U.S. National Library of Medicine
Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.
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