What does cixutumumab mean?
Definitions for cixutumumab
cix·u·tu·mum·ab
This dictionary definitions page includes all the possible meanings, example usage and translations of the word cixutumumab.
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Wiktionary
cixutumumabnoun
A monoclonal antibody used in the treatment of solid tumours.
Wikipedia
Cixutumumab
Cixutumumab (IMC-A12) is a human monoclonal antibody for the treatment of solid tumors.This drug was developed by ImClone Systems, since acquired by Eli Lilly, using phage display technology from Dyax. It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the ligand IGF-1 and subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.
Wikidata
Cixutumumab
Cixutumumab is a monoclonal antibody for the treatment of solid tumors. This drug was developed by ImClone Systems Inc. under the name IMC-A12. It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.
Numerology
Chaldean Numerology
The numerical value of cixutumumab in Chaldean Numerology is: 6
Pythagorean Numerology
The numerical value of cixutumumab in Pythagorean Numerology is: 4
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"cixutumumab." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/cixutumumab>.
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