Definitions for chlorpromazine
klɔrˈprɒm əˌzin, kloʊr-chlor·pro·mazine

Princeton's WordNetRate this definition:0.0 / 0 votes

1. chlorpromazine, Thorazinenoun

   a drug (trade name Thorazine) derived from phenothiazine that has antipsychotic effects and is used as a sedative and tranquilizer

WiktionaryRate this definition:0.0 / 0 votes

1. chlorpromazinenoun

   A tranquillizing drug, CHClNS, used in the treatment of schizophrenia etc.

2. Etymology: From French chloropromazine, corresponding to chlor- + prom(eth)azine.

WikipediaRate this definition:0.0 / 0 votes

1. Chlorpromazine

   Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, severe behavioral problems in children including those with attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given orally (by mouth), by intramuscular injection (injection into a muscle), or intravenously (injection into a vein).Chlorpromazine is in the typical antipsychotic class, and, chemically, is one of the phenothiazines. Its mechanism of action is not entirely clear but believed to be related to its ability as a dopamine antagonist. It also has anti-serotonergic and antihistaminergic properties.Common side effects include movement problems, sleepiness, dry mouth, low blood pressure upon standing, and increased weight. Serious side effects may include the potentially permanent movement disorder tardive dyskinesia, neuroleptic malignant syndrome, severe lowering of the seizure threshold, and low white blood cell levels. In older people with psychosis as a result of dementia it may increase the risk of death. It is unclear if it is safe for use in pregnancy.Chlorpromazine was developed in 1950 and was the first antipsychotic on the market. It is on the World Health Organization's List of Essential Medicines. Its introduction has been labeled as one of the great advances in the history of psychiatry. It is available as a generic medication.

ChatGPTRate this definition:0.0 / 0 votes

1. chlorpromazine

   Chlorpromazine is a prescription medication used in the treatment of various types of mental and mood disorders such as schizophrenia, psychotic disorders, manic phase of bipolar disorder, and severe behavioural problems in children. It falls under the class of drugs known as phenothiazines and works by helping to restore the balance of certain natural substances in the brain. Chlorpromazine can also be used to treat intractable hiccups and can be used with other medication to prevent and treat nausea and vomiting caused by surgery or cancer treatment.

WikidataRate this definition:5.0 / 1 vote

1. Chlorpromazine

   Chlorpromazine is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties used to treat schizophrenia. First synthesized on December 11, 1950, chlorpromazine was the first drug developed with specific antipsychotic action, and would serve as the prototype for the phenothiazine class of drugs, which later grew to comprise several other agents. The introduction of chlorpromazine into clinical use has been described as the single greatest advance in psychiatric care, dramatically improving the prognosis of patients in psychiatric hospitals worldwide. The availability of antipsychotic drugs curtailed indiscriminate use of electroconvulsive therapy and psychosurgery, and was one of the driving forces behind the deinstitutionalization movement. Chlorpromazine works on a variety of receptors in the central nervous system, producing anticholinergic, antidopaminergic, antihistaminic, and weak antiadrenergic effects. Both the clinical indications and side effect profile of CPZ are determined by this broad action: its anticholinergic properties cause constipation, sedation, and hypotension, and help relieve nausea. It also has anxiolytic properties. Its antidopaminergic properties can cause extrapyramidal symptoms such as akathisia and dystonia. It is known to cause tardive dyskinesia, which can be irreversible. In recent years, chlorpromazine has been largely superseded by the newer atypical antipsychotics, which are usually better tolerated, and its use is now restricted to fewer indications. In acute settings, it is often administered as a syrup, which has a faster onset of action than tablets, and can also be given by intramuscular injection. IV administration is very irritating and is not advised; its use is limited to severe hiccups, surgery, and tetanus.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Chlorpromazine

   The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

Matched Categories

1. • Major Tranquilizer
   • Phenothiazine

How to pronounce chlorpromazine?

1. Alex

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Numerology

1. Chaldean Numerology

   The numerical value of chlorpromazine in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of chlorpromazine in Pythagorean Numerology is: 2

Popularity rank by frequency of use

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=chlorpromazine
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Chlorpromazine
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Chlorpromazine
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=chlorpromazine