| Definition of 'cardiac glycosides' |
U.S. National Library of Medicine |
|
1. cardiac glycosides
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
|
|
|
|
|
| Alternative search options for 'cardiac glycosides' |
|
|
|
|
|
|
|
Definitions of cardiac glycosides
