Definitions for carcinoma in situ
This page provides all possible meanings and translations of the word carcinoma in situ
carcinoma in situ, preinvasive cancer(noun)
a cluster of malignant cells that has not yet invaded the deeper epithelial tissue or spread to other parts of the body
Carcinoma in situ
Carcinoma in situ is an early form of cancer that is defined by the absence of invasion of tumor cells into the surrounding tissue, usually before penetration through the basement membrane. In other words, the neoplastic cells proliferate in their normal habitat, hence the name "in situ". For example, carcinoma in situ of the skin, also called Bowen's disease, is the accumulation of neoplastic epidermal cells within the epidermis only, that has failed to penetrate into the deeper dermis. For this reason, CIS will usually not form a tumor. Rather, the lesion is flat or follows the existing architecture of the organ. Some CIS, however, do form tumors, such as in the colon, in the bladder, or in the breast. Many forms of invasive carcinoma originate after progression of a CIS lesion. Therefore, CIS is considered a precursor or incipient form of cancer that may, if left untreated long enough, transform into a malignant neoplasm. When explaining a laboratory report to a patient, most doctors will refer to CIS as "pre-cancer", not cancer. However, because most forms of CIS have a high probability of progression into invasive carcinoma, doctors will usually recommend that the lesion be completely removed. Therefore, CIS is usually treated in much the same way as a malignant tumor.
U.S. National Library of Medicine
Carcinoma in Situ
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
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