Definitions for calreticulin
This page provides all possible meanings and translations of the word calreticulin
A multifunctional protein that binds calcium ions
Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 is a protein that in humans is encoded by the CALR gene. Calreticulin is a multifunctional protein that binds Ca2+ ions, rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal. Calreticulin is located in storage compartments associated with the endoplasmic reticulum. The term "Mobilferrin" is considered to be the same as calreticulin by some sources.
U.S. National Library of Medicine
A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Find a translation for the calreticulin definition in other languages:
Select another language:
Discuss these calreticulin definitions with the community:
Use the citation below to add this definition to your bibliography:
"calreticulin." Definitions.net. STANDS4 LLC, 2014. Web. 31 Jul 2014. <http://www.definitions.net/definition/calreticulin>.