What does brasofensine mean?
Definitions for brasofensine
bra·sofen·sine
This dictionary definitions page includes all the possible meanings, example usage and translations of the word brasofensine.
Wikidata
Brasofensine
Brasofensine is a phenyltropane that had been under development for the treatment of Parkinson's and Alzheimer's disease. Phase II trials were conducted in 1996 and brasofensine was shown to be both effective and well tolerated at a dose of 4 mg, however development was stopped after in vivo cis-anti isomerization of the 2α-methyloxime group was reported. In animal models of Parkinson's disease, brasofensine was effective in stimulating LMA and reversing akinesia. The isomerization of brasofensine is not between the alpha and beta positions on the 2 position of the tropane ring but rather the E/Z isomerization of the imine. It was believed that this process occurs in vivo although it cannot be ruled out as a possibility that some isomerization also occurs prior to ingestion. The-isomer has been consigned the name BMS-205912 In PD, symptoms do not begin to manifest until there has been an 80% reduction in dopaminergic neurons, particularly in the substantia nigra brain region.
Numerology
Chaldean Numerology
The numerical value of brasofensine in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of brasofensine in Pythagorean Numerology is: 1
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"brasofensine." Definitions.net. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.definitions.net/definition/brasofensine>.
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