Definitions for bone resorption
bone re·sorp·tion

WikipediaRate this definition:0.0 / 0 votes

1. Bone resorption

   Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones and release the minerals, resulting in a transfer of calcium from bone tissue to the blood.The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. These are the cells responsible for the resorption of bone. Osteoblasts are generally present on the outer layer of bone, just beneath the periosteum. Attachment of the osteoclast to the osteon begins the process. The osteoclast then induces an infolding of its cell membrane and secretes collagenase and other enzymes important in the resorption process. High levels of calcium, magnesium, phosphate and products of collagen will be released into the extracellular fluid as the osteoclasts tunnel into the mineralized bone. Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatological disorders.The human body is in a constant state of bone remodeling. Bone remodeling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous matrix. Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. Osteocyte activity plays a key role in this process. Conditions that result in a decrease in bone mass can either be caused by an increase in resorption or by a decrease in ossification. During childhood, bone formation exceeds resorption. As the aging process occurs, resorption exceeds formation.Bone resorption rates are much higher in post-menopausal older women due to estrogen deficiency related with menopause. Common treatments include drugs that increase bone mineral density. Bisphosphonates, RANKL inhibitors, SERMs—selective oestrogen receptor modulators, hormone replacement therapy and calcitonin are some of the common treatments. Light weight bearing exercise tends to eliminate the negative effects of bone resorption.

WikidataRate this definition:3.0 / 3 votes

1. Bone resorption

   Bone resorption is the process by which osteoclasts break down bone and release the minerals, resulting in a transfer of calcium from bone fluid to the blood. The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. These are the cells responsible for the resorption of bone. Osteoclasts are generally present on the outer layer of bone, just beneath the periosteum. Attachment of the osteoclast to the osteon begins the process. The osteoclast then induces an infolding of its cell membrane and secretes collagenase and other enzymes important in the resorption process. High levels of calcium, magnesium, phosphate and products of collagen will be released into the extracellular fluid as the osteoclasts tunnel into the mineralized bone. Osteoclasts are also prominent in the tissue destruction commonly found in psoriatic arthritis and other rheumatology related disorders. Bone resorption can also be the result of disuse and the lack of stimulus for bone maintenance. Astronauts, for instance will undergo a certain amount of bone resorption due to the lack of gravity providing the proper stimulus for bone maintenance. During childhood, bone formation exceeds resorption, but as the aging process occurs, resorption exceeds formation.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Bone Resorption

   Bone loss due to osteoclastic activity.

How to pronounce bone resorption?

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How to say bone resorption in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of bone resorption in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of bone resorption in Pythagorean Numerology is: 5

Examples of bone resorption in a Sentence

1. Robert McLean:

   Denosumab also decreases bone resorption by inhibiting maturation of osteoclasts through binding to a receptor on the surface of 'pre-osteoclast cells,'.

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Bone_Resorption
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=bone resorption