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1. (n.) amyotrophic lateral sclerosis
a nervous system disease in which degeneration of motor neurons in the brain stem and spinal cord leads to atrophy and paralysis of the voluntary muscles.
an historian.; 14 dollars an ounce; 55 miles an hour.
Etymology: (bef. 950; ME; OE ānone)
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| Definition of 'amyotrophic lateral sclerosis' |
Princeton's WordNet |
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1. (noun) amyotrophic lateral sclerosis, ALS, Lou Gehrig's disease
thickening of tissue in the motor tracts of the lateral columns and anterior horns of the spinal cord; results in progressive muscle atrophy that starts in the limbs
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| Definition of 'amyotrophic lateral sclerosis' |
U.S. National Library of Medicine |
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1. amyotrophic lateral sclerosis
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
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Definitions of amyotrophic lateral sclerosis 
