What does alanine racemase mean?
Definitions for alanine racemase
ala·nine race·mase
This dictionary definitions page includes all the possible meanings, example usage and translations of the word alanine racemase.
Wikipedia
Alanine racemase
In enzymology, an alanine racemase (EC 5.1.1.1) is an enzyme that catalyzes the chemical reaction L-alanine ⇌ {\displaystyle \rightleftharpoons } D-alanineHence, this enzyme has one substrate, L-alanine, and one product, D-alanine. This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is alanine racemase. This enzyme is also called L-alanine racemase. This enzyme participates in alanine and aspartate metabolism and D-alanine metabolism. It employs one cofactor, pyridoxal phosphate. At least two compounds, 3-Fluoro-D-alanine and D-Cycloserine are known to inhibit this enzyme. The D-alanine produced by alanine racemase is used for peptidoglycan biosynthesis. Peptidoglycan is found in the cell walls of all bacteria, including many which are harmful to humans. The enzyme is absent in higher eukaryotes but found everywhere in prokaryotes, making alanine racemase a great target for antimicrobial drug development. Alanine racemase can be found in some invertebrates.Bacteria can have one (alr gene) or two alanine racemase genes. Bacterial species with two genes for alanine racemase have one that is continually expressed and one that is inducible, which makes it difficult to target both genes for drug studies. However, knockout studies have shown that without the alr gene being expressed, the bacteria would need an external source of D-alanine in order to survive. Therefore, the alr gene is a feasible target for antimicrobial drugs.
Wikidata
Alanine racemase
In enzymology, an alanine racemase is an enzyme that catalyzes the chemical reaction Hence, this enzyme has one substrate, L-alanine, and one product, D-alanine. This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is alanine racemase. This enzyme is also called L-alanine racemase. This enzyme participates in alanine and aspartate metabolism and D-alanine metabolism. It employs one cofactor, pyridoxal phosphate. At least two compounds, 3-Fluoro-D-alanine and D-Cycloserine are known to inhibit this enzyme.
U.S. National Library of Medicine
Alanine Racemase
A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. EC 5.1.1.1.
Numerology
Chaldean Numerology
The numerical value of alanine racemase in Chaldean Numerology is: 9
Pythagorean Numerology
The numerical value of alanine racemase in Pythagorean Numerology is: 4
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"alanine racemase." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/alanine+racemase>.
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