Definitions for acylation
the process of introducing an acyl group into a compound
The process of adding an acyl group to a compound.
In chemistry, acylation is the process of adding an acyl group to a compound. The compound providing the acyl group is called the acylating agent. Because they form a strong electrophile when treated with some metal catalysts, acyl halides are commonly used as acylating agents. For example, Friedel-Crafts acylation uses acetyl chloride, CH3COCl, as the agent and aluminum chloride as a catalyst to add an ethanoyl group to benzene: The mechanism of this reaction is electrophilic substitution. Acyl halides and anhydrides of carboxylic acids are also commonly used acylating agents to acylate amines to form amides or acylate alcohols to form esters. The amines and alcohols are nucleophiles; the mechanism is nucleophilic addition-elimination. Succinic acid is also commonly used in a specific type of acylation called succination. Oversuccination occurs when more than one succinate adds to a single compound.
U.S. National Library of Medicine
The addition of an organic acid radical into a molecule.
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