Definitions for abzyme
This page provides all possible meanings and translations of the word abzyme
An antibody with catalytic properties.
Origin: From ab (an abbreviation for antibody) + -zyme (meaning enzyme).
An abzyme, also called catmab, is a monoclonal antibody with catalytic activity. Molecules which are modified to gain new catalytic activity are called synzymes. Abzymes are usually artificial constructs, but are also found in normal humans and in patients with autoimmune diseases such as systemic lupus erythematosus, where they can bind to and hydrolyze DNA. Abzymes are potential tools in biotechnology, e.g., to perform specific actions on DNA. They are also useful in hydrolysis of esters. Rate of hydrolysis was increased 100 times. Enzymes function by lowering the activation energy of the transition state, thereby catalyzing the formation of an otherwise less-favorable molecular intermediate between reactants and products. If an antibody is developed to stabilize a molecule that's similar to an unstable intermediate of another reaction, the developed antibody will enzymatically bind to and stabilize the intermediate state, thus catalyzing the reaction. A new and unique type of enzyme is produced.
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