What does abelson murine leukemia virus mean?
Definitions for abelson murine leukemia virus
abel·son murine leukemia virus
This dictionary definitions page includes all the possible meanings, example usage and translations of the word abelson murine leukemia virus.
Wikidata
Abelson murine leukemia virus
The Abelson murine leukemia virus is a retrovirus used to induce transformation of murine lymphoid cells. As a retrovirus, it has a single-stranded, positive sense RNA genome which replicates via a DNA intermediate mediated by a reverse transcriptase. The Abelson murine leukemia virus is named for the American pediatrician Herbert T. Abelson, who first described and isolated it. A-MuLV causes a rapidly progressive lymphosarcoma known as Abelson disease in mice, which is a type of leukemia that does not involve the thymus. However, this is only possible when the host cell is co-infected with a helper virus which provides functions it needs to be able to replicate which it does not code for in its own genome such as a reverse transcriptase and some major structural proteins. As such, A-MuLV can be described as a dependovirus. A highly efficient helper virus commonly used when growing A-MuLV in vitro is Moloney murine leukemia virus. It causes leukemia directly by interfering with the normal growth and differentiation processes of lymphocytes. It can infect B-cells which was shown by the fact that some tumor cells can be seen to have immunoglobulins on their surface although most tumor cells do not have characteristic receptors on their surface indicating that they are undifferentiated cells. In vitro studies have shown that lymphocyte infection produces tumor cell populations comprising three types of cells: stable productive cells, non-productive cells and cells which produced defective virus particles which are not infective.
U.S. National Library of Medicine
Abelson murine leukemia virus
A replication-defective strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with FRIEND MURINE LEUKEMIA VIRUS; MOLONEY MURINE LEUKEMIA VIRUS; or RAUSCHER VIRUS.
Numerology
Chaldean Numerology
The numerical value of abelson murine leukemia virus in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of abelson murine leukemia virus in Pythagorean Numerology is: 8
Translations for abelson murine leukemia virus
From our Multilingual Translation Dictionary
- abelson小鼠白血病病毒Chinese
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"abelson murine leukemia virus." Definitions.net. STANDS4 LLC, 2024. Web. 23 Apr. 2024. <https://www.definitions.net/definition/abelson+murine+leukemia+virus>.
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