What does Toll-like receptor mean?
Definitions for Toll-like receptor
toll-like re·cep·tor
This dictionary definitions page includes all the possible meanings, example usage and translations of the word Toll-like receptor.
Wikipedia
Toll-like receptor
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have reached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Humans lack genes for TLR11, TLR12 and TLR13 and mice lack a functional gene for TLR10. TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10 are located on the cell membrane, whereas TLR3, TLR7, TLR8, and TLR9 are located in intracellular vesicles (because they are sensors of nucleic acids).TLRs received their name from their similarity to the protein coded by the toll gene.
Wikidata
Toll-like receptor
Toll-like receptors are a class of proteins that play a key role in the innate immune system as well as the digestive system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. They receive their name from their similarity to the protein coded by the Toll gene identified in Drosophila in 1985 by Christiane Nüsslein-Volhard. The gene in question, when mutated, makes the Drosophila flies look unusual. The researchers were so surprised that they spontaneously shouted out in German "Das ist ja toll!" which translates as "That's great!"
Numerology
Chaldean Numerology
The numerical value of Toll-like receptor in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of Toll-like receptor in Pythagorean Numerology is: 7
Translations for Toll-like receptor
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"Toll-like receptor." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/Toll-like+receptor>.
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