Definitions for Porphyria
pɔrˈfɪər i ə, -ˈfaɪ ri əpor·phyr·i·a

Princeton's WordNetRate this definition:0.0 / 0 votes

1. porphyrianoun

   a genetic abnormality of metabolism causing abdominal pains and mental confusion

WiktionaryRate this definition:0.0 / 0 votes

1. porphyrianoun

   Any of several usually hereditary abnormalities of porphyrin metabolism characterized by excretion of excess porphyrins in the urine.

WikipediaRate this definition:0.0 / 0 votes

1. Porphyria

   Porphyria is a group of liver disorders in which substances called porphyrins build up in the body, negatively affecting the skin or nervous system. The types that affect the nervous system are also known as acute porphyria, as symptoms are rapid in onset and short in duration. Symptoms of an attack include abdominal pain, chest pain, vomiting, confusion, constipation, fever, high blood pressure, and high heart rate. The attacks usually last for days to weeks. Complications may include paralysis, low blood sodium levels, and seizures. Attacks may be triggered by alcohol, smoking, hormonal changes, fasting, stress, or certain medications. If the skin is affected, blisters or itching may occur with sunlight exposure.Most types of porphyria are inherited from one or both of a person's parents and are due to a mutation in one of the genes that make heme. They may be inherited in an autosomal dominant, autosomal recessive, or X-linked dominant manner. One type, porphyria cutanea tarda, may also be due to hemochromatosis (increased iron in the liver), hepatitis C, alcohol, or HIV/AIDS. The underlying mechanism results in a decrease in the amount of heme produced and a build-up of substances involved in making heme. Porphyrias may also be classified by whether the liver or bone marrow is affected. Diagnosis is typically made by blood, urine, and stool tests. Genetic testing may be done to determine the specific mutation.Treatment depends on the type of porphyria and the person's symptoms. Treatment of porphyria of the skin generally involves the avoidance of sunlight, while treatment for acute porphyria may involve giving intravenous heme or a glucose solution. Rarely, a liver transplant may be carried out.The precise prevalence of porphyria is unclear, but it is estimated to affect between 1 and 100 per 50,000 people. Rates are different around the world. Porphyria cutanea tarda is believed to be the most common type. The disease was described as early as 370 BC by Hippocrates. The underlying mechanism was first described by German physiologist and chemist Felix Hoppe-Seyler in 1871. The name porphyria is from the Greek πορφύρα, porphyra, meaning "purple", a reference to the color of the urine that may be present during an attack.

ChatGPTRate this definition:0.0 / 0 votes

1. porphyria

   Porphyria refers to a group of rare genetic disorders that result from a buildup of natural chemicals that produce porphyrin in the body, a substance vital for the function of hemoglobin - a protein in the blood that links to porphyrin, binds iron, and carries oxygen to cells and carbon dioxide away from cells. Symptoms and severity of porphyria can vary widely and mainly affect the nervous system, skin, or both. Treatment focuses on managing symptoms and preventing complications.

WikidataRate this definition:0.0 / 0 votes

1. Porphyria

   The porphyrias are a group of rare inherited or acquired disorders of certain enzymes that normally participate in the production of porphyrins and heme. They manifest with either neurological complications or skin problems or occasionally both. Porphyrias are classified in two ways, by symptoms and by pathophysiology. Symptomatically, acute porphyrias primarily present with nervous system involvement, often with severe abdominal pain, vomiting, neuropathy and mental disturbances. Cutaneous porphyrias present with skin manifestations often after exposure to sun due to the accumulation of excess porphyrins near the surface of the skin. Physiologically, porphyrias are classified as hepatic or erythropoietic based on the sites of accumulation of heme precursors, either in the liver or bone marrow and red blood cells. The term "porphyria" is derived from the Greek πορφύρα, porphyra, meaning "purple pigment". The name is likely to have been a reference to the purple discolouration of feces and urine when exposed to light in patients during an attack. Although original descriptions are attributed to Hippocrates, the disease was first explained biochemically by Felix Hoppe-Seyler in 1871 and acute porphyrias were described by the Dutch physician Barend Stokvis in 1889.

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1. • Genetic Disease

How to pronounce Porphyria?

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Numerology

1. Chaldean Numerology

   The numerical value of Porphyria in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of Porphyria in Pythagorean Numerology is: 9

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References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=Porphyria
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Porphyria
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Porphyria
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=Porphyria