Definitions for Paclitaxel
pa·cli·tax·el

WiktionaryRate this definition:0.0 / 0 votes

1. paclitaxelnoun

   A particular drug used in chemotherapy.

WikipediaRate this definition:0.0 / 0 votes

1. Paclitaxel

   Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer. This includes ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by intravenous injection. There is also an albumin-bound formulation.Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea. Other serious side effects include heart problems, increased risk of infection, and lung inflammation. There are concerns that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function of microtubules during cell division.Paclitaxel was first isolated in 1971 from the Pacific yew and approved for medical use in 1993. It is on the World Health Organization's List of Essential Medicines. It has been made from precursors, and more recently through cell culture.

WikidataRate this definition:0.0 / 0 votes

1. Paclitaxel

   Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel. When it was developed commercially by Bristol-Myers Squibb, the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane. Paclitaxel is used to treat patients with lung, ovarian, breast, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis. Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes. It was the subject of a notable total synthesis by Robert A. Holton. While offering substantial improvement in patient care, paclitaxel has been a relatively controversial drug. There was originally concern because of the environmental impact of its original sourcing from the Pacific yew. In addition, the assignment of rights to Bristol-Myers Squibb, and even the name itself, were the subject of public debate and Congressional hearings.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Paclitaxel

   A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.

How to pronounce Paclitaxel?

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Numerology

1. Chaldean Numerology

   The numerical value of Paclitaxel in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of Paclitaxel in Pythagorean Numerology is: 4

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Paclitaxel
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Paclitaxel
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=Paclitaxel