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1. (n.) methotrexate
a toxic folic acid analogue, C
Etymology: (1950–55; metho (xy )- +trexate, of unclear derivation)
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| Definition of 'Methotrexate' |
Princeton's WordNet |
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1. (noun) methotrexate, methotrexate sodium, amethopterin
toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
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| Definition of 'Methotrexate' |
U.S. National Library of Medicine |
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1. Methotrexate
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
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Definitions of Methotrexate 
