Definitions for LEVALLORPHAN
lev·al·lor·phan

Princeton's WordNetRate this definition:0.0 / 0 votes

1. levallorphan, Lorfannoun

   drug (trade name Lorfan) that is related to morphine but that counteracts the respiratory depression produced by morphine poisoning but without affecting its analgesic effects

WiktionaryRate this definition:0.0 / 0 votes

1. levallorphannoun

   An opioid antagonist from the morphinan family.

WikipediaRate this definition:0.0 / 0 votes

1. Levallorphan

   Levallorphan (INN, BAN) (brand names Lorfan, Naloxifan, Naloxiphan), also known as levallorphan tartrate (USAN), is an opioid modulator of the morphinan family used as an opioid analgesic and opioid antagonist/antidote. It acts as an antagonist of the μ-opioid receptor (MOR) and as an agonist of the κ-opioid receptor (KOR), and as a result, blocks the effects of stronger agents with greater intrinsic activity such as morphine whilst simultaneously producing analgesia.Levallorphan was formerly widely used in general anesthesia, mainly to reverse the respiratory depression produced by opioid analgesics and barbiturates used for induction of surgical anaesthesia whilst maintaining a degree of analgesia (via KOR agonism). It is now less commonly employed for this purpose as the newer drug naloxone tends to be used instead. Levallorphan was also used in combination with opioid analgesics to reduce their side effects, mainly in obstetrics, and a very small dose of levallorphan used alongside a full agonist of the MOR can produce greater analgesia than when the latter is used by itself. The combination of levallorphan with pethidine (meperidine) was indeed used so frequently, a standardized formulation was made available, known as Pethilorfan.As an agonist of the KOR, levallorphan can produce severe mental reactions at sufficient doses including hallucinations, dissociation, and other psychotomimetic effects, dysphoria, anxiety, confusion, dizziness, disorientation, derealization, feelings of drunkenness, delusions, paranoia, and bizarre, unusual, or disturbing dreams.

ChatGPTRate this definition:0.0 / 0 votes

1. levallorphan

   Levallorphan is a synthetic compound used in research. It belongs to the class of morphinan drugs that act as an opioid receptor antagonist. It was previously used as an analgesic medication for pain relief. However, it is primarily used today in pharmacological research to investigate the opioid system, particularly in studies addressing opioid addiction.

WikidataRate this definition:0.0 / 0 votes

1. Levallorphan

   Levallorphan is a drug of the morphinan family which is used as an opioid antidote or antagonist. It acts as an antagonist on μ-opioid receptor and agonist on kappa receptors hence called partial agonist, and as a result, blocks the effects of stronger agents with greater intrinsic activity such as morphine or endogenous β-endorphin. Levallorphan was formerly widely used in general anaesthesia, mainly to reverse the respiratory depression produced by the opioid analgesics and barbiturates which are used for induction of surgical anaesthesia, although it is now less common as the newer drug naloxone tends to be used instead. It was also used in combination with opioids to reduce their side effects, mainly in obstetrics, and when a very small dose of levallorphan is used alongside an opioid full agonist this can in fact produce greater analgesia than when the agonist is used by itself. The combination of levallorphan with pethidine was indeed used so frequently that a standardized formulation was made available, known as Pethilorfan.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Levallorphan

   An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)

Matched Categories

1. • Drug

How to pronounce LEVALLORPHAN?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say LEVALLORPHAN in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of LEVALLORPHAN in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of LEVALLORPHAN in Pythagorean Numerology is: 1

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=LEVALLORPHAN
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Levallorphan
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Levallorphan
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=LEVALLORPHAN