Definitions for Glucocorticoidˌglu koʊˈkɔr tɪˌkɔɪd
This page provides all possible meanings and translations of the word Glucocorticoid
Random House Webster's College Dictionary
glu•co•cor•ti•coidˌglu koʊˈkɔr tɪˌkɔɪd(n.)
any of a class of steroid hormones that are produced by the adrenal cortex under conditions of stress and that inhibit immunologic reactions.
Origin of glucocorticoid:
a steroid hormone that is produced by the adrenal cortex of animals; affects functioning of gonads and has anti-inflammatory activity
Any of a group of steroid hormones, produced by the adrenal cortex, that are involved in metabolism and have anti-inflammatory properties.
Glucocorticoids are a class of steroid hormones that bind to the glucocorticoid receptor, which is present in almost every vertebrate animal cell. The name glucocorticoid derives from its role in the regulation of the metabolism of glucose, its synthesis in the adrenal cortex, and its steroidal structure. GCs are part of the feedback mechanism in the immune system that turns immune activity down. They are therefore used in medicine to treat diseases caused by an overactive immune system, such as allergies, asthma, autoimmune diseases and sepsis. GCs have many diverse effects, including potentially harmful side effects, and as a result are rarely sold over the counter. They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer. This includes mainly inhibitory effects on lymphocyte proliferation and mitigation of side effects of anticancer drugs. GCs cause their effects by binding to the glucocorticoid receptor. The activated GR complex, in turn, up-regulates the expression of anti-inflammatory proteins in the nucleus and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus.
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