Definitions for CYLD

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  1. CYLD

    Cylindromatosis, also known as CYLD, is a human gene. This gene encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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