What does Bafilomycin mean?
Definitions for Bafilomycin
bafilomycin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word Bafilomycin.
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Wiktionary
bafilomycinnoun
Any of a family of toxic macrolide antibiotics derived from Streptomyces griseus
Wikipedia
Bafilomycin
The bafilomycins are a family of macrolide antibiotics produced from a variety of Streptomycetes. Their chemical structure is defined by a 16-membered lactone ring scaffold. Bafilomycins exhibit a wide range of biological activity, including anti-tumor, anti-parasitic, immunosuppressant and anti-fungal activity. The most used bafilomycin is bafilomycin A1, a potent inhibitor of cellular autophagy. Bafilomycins have also been found to act as ionophores, transporting potassium K+ across biological membranes and leading to mitochondrial damage and cell death.Bafilomycin A1 specifically targets the vacuolar-type H+ -ATPase (V-ATPase) enzyme, a membrane-spanning proton pump that acidifies either the extracellular environment or intracellular organelles such as the lysosome. At higher micromolar concentrations, bafilomycin A1 also acts on P-type ATPases, which have a phosphorylated transitional state.Bafilomycin A1 serves as an important tool compound in many in vitro research applications; however, its clinical use is limited by a substantial toxicity profile.
Wikidata
Bafilomycin
The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. Bafilomycin has antibacterial, antifungal, antineoplastic, immunosuppressive activities.In addition, bafilomycin A1 has antimalarial activity It has been shown to decrease multi-drug resistance. Bafilomycin B1 has been mentioned as a potential antiosteoporotic agent in treating bone lytic diseases.
Numerology
Chaldean Numerology
The numerical value of Bafilomycin in Chaldean Numerology is: 9
Pythagorean Numerology
The numerical value of Bafilomycin in Pythagorean Numerology is: 1
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"Bafilomycin." Definitions.net. STANDS4 LLC, 2024. Web. 28 Mar. 2024. <https://www.definitions.net/definition/Bafilomycin>.
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