What does Autosomal Dominant Polycystic Kidney Disease mean?
Definitions for Autosomal Dominant Polycystic Kidney Disease
au·to·so·ma·l dom·i·nan·t po·ly·cys·tic kid·ney dis·ease
This dictionary definitions page includes all the possible meanings, example usage and translations of the word Autosomal Dominant Polycystic Kidney Disease.
Wikipedia
Autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, life-threatening inherited human disorders and the most common hereditary kidney disease. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. It is also the most common of the inherited cystic kidney diseases — a group of disorders with related but distinct pathogenesis, characterized by the development of renal cysts and various extrarenal manifestations, which in case of ADPKD include cysts in other organs, such as the liver, seminal vesicles, pancreas, and arachnoid membrane, as well as other abnormalities, such as intracranial aneurysms and dolichoectasias, aortic root dilatation and aneurysms, mitral valve prolapse, and abdominal wall hernias. Over 50% of patients with ADPKD eventually develop end stage kidney disease and require dialysis or kidney transplantation. ADPKD is estimated to affect at least one in every 1000 individuals worldwide, making this disease the most common inherited kidney disorder with a diagnosed prevalence of 1:2000 and incidence of 1:3000-1:8000 in a global scale.
Wikidata
Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease is an inherited systemic disorder that predominantly affects the kidneys, but may affect other organs including the liver, pancreas, brain, and arterial blood vessels. Approximately 50% of people with this disease will develop end stage kidney disease and require dialysis or kidney transplantation. Progression to end stage kidney disease usually happens in the 4th to 6th decades of life. Autosomal dominant polycystic kidney disease occurs worldwide and affects about 1 in 400 to 1 in 1000 people. Defects in two genes are thought to be responsible for ADPKD. In 85% of patients, ADPKD is caused by mutations in the gene PKD1 on chromosome 16; in 15% of patients mutations in PKD2 are causative. Autosomal recessive polycystic kidney disease is a distinct disease that also leads to cysts in the kidneys and liver, typically presents in childhood, only affects about 1 in 20,000 people and has different causes and prognosis.
Numerology
Chaldean Numerology
The numerical value of Autosomal Dominant Polycystic Kidney Disease in Chaldean Numerology is: 6
Pythagorean Numerology
The numerical value of Autosomal Dominant Polycystic Kidney Disease in Pythagorean Numerology is: 7
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"Autosomal Dominant Polycystic Kidney Disease." Definitions.net. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.definitions.net/definition/Autosomal+Dominant+Polycystic+Kidney+Disease>.
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