| Definition of '5-aminolevulinate synthetase' |
U.S. National Library of Medicine |
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1. 5-aminolevulinate synthetase
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
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Definitions of 5-aminolevulinate synthetase
