What does 2-Amino-5-PhosphonoValerate mean?
Definitions for 2-Amino-5-PhosphonoValerate
2-amino-5-phos·pho·no·valer·ate
This dictionary definitions page includes all the possible meanings, example usage and translations of the word 2-Amino-5-PhosphonoValerate.
Wikipedia
2-Amino-5-phosphonovalerate
AP5 (also known as APV, (2R)-amino-5-phosphonovaleric acid, or (2R)-amino-5-phosphonopentanoate) is a chemical compound used as a biochemical tool to study various cellular processes. It is a selective NMDA receptor antagonist that competitively inhibits the ligand (glutamate) binding site of NMDA receptors. AP5 blocks NMDA receptors in micromolar concentrations (~50 μM). AP5 blocks the cellular analog of classical conditioning in the sea slug Aplysia californica, and has similar effects on Aplysia long-term potentiation (LTP), since NMDA receptors are required for both. It is sometimes used in conjunction with the calcium chelator BAPTA to determine whether NMDARs are required for a particular cellular process. AP5/APV has also been used to study NMDAR-dependent LTP in the mammalian hippocampus.In general, AP5 is very fast-acting within in vitro preparations, and can block NMDA receptor action at a reasonably small concentration. The active isomer of AP5 is considered to be the D configuration, although many preparations are available as a racemic mixture of D- and L-isomers. It is useful to isolate the action of other glutamate receptors in the brain, i.e., AMPA and kainate receptors. AP5 can block the conversion of a silent synapse to an active one, since this conversion is NMDA receptor-dependent.
U.S. National Library of Medicine
2-Amino-5-phosphonovalerate
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Numerology
Chaldean Numerology
The numerical value of 2-Amino-5-PhosphonoValerate in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of 2-Amino-5-PhosphonoValerate in Pythagorean Numerology is: 1
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"2-Amino-5-PhosphonoValerate." Definitions.net. STANDS4 LLC, 2024. Web. 29 Mar. 2024. <https://www.definitions.net/definition/2-Amino-5-PhosphonoValerate>.
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