Definitions for 12-hydroxy-5,8,10,14-eicosatetraenoic acid

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  1. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

    A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)


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