| Definition of '11-beta-hydroxysteroid dehydrogenase type 2' |
U.S. National Library of Medicine |
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1. 11-beta-hydroxysteroid dehydrogenase type 2
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
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Definitions of 11-beta-hydroxysteroid dehydrogenase type 2
