Definitions for 1-phosphatidylinositol 3-kinase

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U.S. National Library of Medicine

  1. 1-Phosphatidylinositol 3-Kinase

    An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, V(D)J recombination and cell cycle checkpoints. EC 2.7.1.137.

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