Definitions for 1-alkyl-2-acetylglycerophosphocholine esterase

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U.S. National Library of Medicine

  1. 1-Alkyl-2-acetylglycerophosphocholine Esterase

    A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

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